Neurobiology of Learning and Memory
نویسندگان
چکیده
Within the brain, the inflammatory cytokine interleukin-1 (IL-1) mediates illnessassociated neural, neuroendocrine, and behavioral responses; however, its role in normal neurobehavioral processes is not clear. To examine the role of IL-1 signaling in memory, we infused Long–Evans rats intracerebroventricularly with IL-1b (10 ng/rat), IL-1 receptor antagonist (IL-1ra, 100 mg/rat), or saline immediately following a learning task and tested memory functioning 1–8 days later. In the Morris water maze (MWM), IL-1ra caused memory impairment in the hippocampusdependent, spatial version, whereas IL-1b had no effect. Neither IL-1b nor IL-1ra influenced the hippocampus-independent, nonspatial version of the MWM. In the passive avoidance response, which also depends on hippocampal functioning, IL1ra caused memory impairment, and IL-1b caused memory improvement. These results suggest that IL-1 signaling within the hippocampus plays a critical role in learning and memory processes. q 2002 Elsevier Science (USA)
منابع مشابه
Alterations in adult hippocampal neurogenesis, aberrant protein s-nitrosylation, and associated spatial memory loss in streptozotocin-induced diabetes mellitus type 2 mice
Objective(s): Epidemiological and biochemical studies conducted over the past two decades have established a strong link between type 2 diabetes mellitus (T2DM) and Alzheimer’s disease (AD). However, the exact mechanisms through which aberrations in insulin signaling associated with T2DM contribute to cognitive decline are not yet known. Materials and Methods: In an effort to explore possible m...
متن کاملSpatial memory and changes in expression of genes of neurotrophic factors in adult rat brain after fractionated whole brain irradiation
Background: Ionizing radiation causes cognitive impairment in adult brain. However, the effects of various irradiation protocols with fractionated fixed total dose on hippocampal function have not yet been studied. Materials and Methods: Fractionated whole brain irradiation with a total dose of 36 Gy was performed according to the following protocols: 2Gy-18 fractions (2Gy*18), 4Gy-9 fraction (...
متن کاملThe Neurobiology of Learning and Memory
Study of the neurobiology of learning and memory is in a most exciting phase. Behavioral studies in animals are characterizing the categories and properties of learning and memory; essential memory trace circuits in the brain are being defined and localized in mammalian models; work on human memory and the brain is identifying neuronal systems involved in memory; the neuronal, neurochemical, mo...
متن کاملInsular cortex is involved in consolidation of object recognition memory.
Federico Bermudez-Rattoni, Shoki Okuda, Benno Roozendaal, and James L. McGaugh Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine, California 92697-3800, USA; Departamento de Neurociencias, Instituto de Fisiologı́a Celular, Universidad Nacional Autónoma de México, México D.F., 04510, México; CNS Disorder Research, Tsuk...
متن کاملNeurobiology of behaviour. Editorial overview.
John H Byrne is currently the Professor and Chairman of the Department of Neurobiology and Anatomy and Director of the Neuroscience Research Center at the University of Texas Medical School at Houston. He is also the Director of the WM Keck Center for the Neurobiology of Learning and Memory at the UT Health Science Center. His research uses a combination of experimental and computational approa...
متن کاملTime to rethink the neural mechanisms of learning and memory.
Most studies in the neurobiology of learning assume that the underlying learning process is a pairing - dependent change in synaptic strength that requires repeated experience of events presented in close temporal contiguity. However, much learning is rapid and does not depend on temporal contiguity, which has never been precisely defined. These points are well illustrated by studies showing th...
متن کامل